Analytical Data
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Gene name
TRPM4
- Application
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Alternative Names
LTRPC4
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Species
Human
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Source
HEK293
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Tag
C-Flag
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8TD43-1
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Expression Region
V2-D1214
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Protein Length
Partial
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Molecular Weight
135.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TRPM4 (transient receptor potential melastatin 4) is a calcium-activated monovalent cation channel that plays a crucial role in various physiological processes, including cardiac function, neuronal excitability, and immune responses. Research on TRPM4 has gained momentum due to its involvement in several diseases, such as cardiac arrhythmias, hypertension, and neurodegenerative disorders. The channel is known to influence cell membrane potential and intracellular calcium levels, thereby modulating cellular signaling pathways. Because of its importance in health and disease, understanding the mechanistic details of TRPM4 function is essential. Recombinant protein studies of TRPM4 facilitate the examination of its structure, gating mechanisms, and interaction with other cellular components. These studies often involve the expression of TRPM4 in heterologous systems, allowing researchers to isolate the protein and analyze its biophysical properties. Additionally, TRPM4 serves as a potential therapeutic target, making its detailed characterization significant for drug discovery efforts. Overall, research on TRPM4 recombinant protein not only enhances our understanding of its biological roles but also opens up avenues for novel therapeutic interventions in diseases associated with TRPM4 dysregulation.
