Analytical Data
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Gene name
ANAPC10
- Application
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Alternative Names
Cyclosome subunit 10
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UM13
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Expression Region
1-185aa
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Molecular Weight
48.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ANAPC10, a crucial component of the Anaphase Promoting Complex/Cyclosome (APC/C), plays a significant role in cell cycle regulation by facilitating the ubiquitination and subsequent degradation of cell cycle inhibitors and other regulatory proteins. This process is vital for the proper progression of mitosis and the prevention of uncontrolled cell growth, which can lead to cancer. Research into ANAPC10 has gained momentum due to its potential implications in oncology, as alterations in APC/C function are often associated with tumorigenesis. Studies have shown that mutations or dysregulation of ANAPC10 can affect the activity of the APC/C, leading to disrupted cell cycle control. Consequently, understanding the molecular mechanisms governing ANAPC10's function and its interactions with other cell cycle regulators may provide insights into novel therapeutic targets for cancer treatment. Additionally, the study of ANAPC10's reconstitution into functional complexes helps enhance our comprehension of its structural and functional properties, paving the way for targeted drug development and further elucidating its role in cellular homeostasis and disease.
