Analytical Data
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Gene name
GZMK
- Application
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Alternative Names
GZM-K; TRYP2; PRSS; Serine Protease,Granzyme 3; Tryptase II; Fragmentin-3; Granzyme-3; NK-tryptase-2
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O35205
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Expression Region
Gln44~Val227
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Molecular Weight
24kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GZMK, or granulocyte aminopeptidase M, is a member of the peptidase M family and plays a significant role in immune responses and inflammation. Recent studies have emphasized its potential implications in various diseases, particularly in cancer and autoimmune disorders. The protein is primarily expressed in activated T cells and plays a crucial role in regulating immune cell functions and mediating cellular interactions. Its involvement in the processing of peptides for major histocompatibility complex (MHC) class II presentation enhances our understanding of T cell activation and the adaptive immune system. Research into GZMK recombinant proteins has gained momentum due to their potential applications in immunotherapy and vaccine development. By elucidating the structure-function relationship and the underlying mechanisms of GZMK, scientists aim to leverage its unique properties to enhance anti-tumor responses and modulate immune tolerance. Furthermore, the production of recombinant GZMK proteins facilitates the exploration of their biochemical properties, opening avenues for therapeutic interventions. Understanding GZMK's functional dynamics could lead to innovative strategies for treating immune-related diseases and improving vaccine efficacy in the context of infectious diseases and cancer. As such, GZMK has emerged as a promising target in both basic and applied biomedical research, warranting further investigation into its role in health and disease.
