Analytical Data
-
基因名
APOBEC3C
- Application
-
别名
APOBEC1-like Phorbolin I
-
种属
Human
-
表达系统
E. coli
-
标签
N- GST
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q9NRW3
-
表达区间
1-190aa
-
分子量
49.8 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
APOBEC3C (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3C) is a member of the APOBEC family of cytidine deaminases, which play a crucial role in the innate immune defense against viral infections, particularly retroviruses. This enzyme exhibits the ability to edit RNA and DNA by converting cytosine to uracil, thereby inducing mutations that can inhibit viral replication. Research has revealed that APOBEC3C specifically targets the genomic RNA of HIV-1 and other retroviruses, thereby acting as a potent antiviral factor. Studies have demonstrated that the activity of APOBEC3C is modulated by various factors including its interaction with the viral proteins and cellular factors, which can enhance or inhibit its antiviral effects. Notably, some viruses have evolved mechanisms to counteract the action of APOBEC3C, highlighting the ongoing evolutionary arms race between host defense mechanisms and viral strategies. As such, understanding the structure, function, and regulation of APOBEC3C is critical for developing potential therapeutic strategies aimed at enhancing its antiviral activity or inhibiting viral countermeasures. The ongoing research into its restructured protein forms aims to elucidate its mechanism of action in greater detail and potentially exploit this knowledge for therapeutic purposes, making APOBEC3C a significant focus in virology and immunology studies.
