Analytical Data
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基因名
TXNRD2
- Application
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别名
Selenoprotein Z ;SelZTR-betaThioredoxin reductase TR3
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NNW7
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表达区间
37-524aa
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分子量
68.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TXNRD2, or thioredoxin reductase 2, is a crucial enzyme that plays a significant role in cellular redox homeostasis, primarily located in mitochondria. It is part of the thioredoxin system, which is vital for maintaining the balance of reactive oxygen species (ROS) and protecting cells from oxidative stress. Research indicates that TXNRD2 is involved in various cellular processes, including apoptosis, cell proliferation, and signaling pathways linked to metabolic diseases and cancers. Mutations or dysregulation of TXNRD2 have been associated with several pathological conditions, highlighting its potential as a therapeutic target. Given its importance, there is a growing interest in the recombinant production of TXNRD2 to facilitate in-depth studies of its structure-function relationships, regulatory mechanisms, and interactions with other biomolecules. Recombinant TXNRD2 not only allows for the examination of its enzymatic activity in controlled environments but also aids in the development of inhibitors that may have clinical relevance in treating diseases characterized by oxidative stress. Understanding the function and regulation of TXNRD2 through recombinant techniques is essential for elucidating its role in health and disease, paving the way for innovative therapeutic strategies.
