Analytical Data
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Gene name
PBLD
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简介
PBLD protein, also known as phenazine biosynthetic domain protein, is a protein involved in a variety of cellular activities. Serval researches indicatethat the PBLD protein interacts with UNRIP/MAWD. PBLD Protein, Human (His) is the recombinant human-derived PBLD protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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Alternative Names
Phenazine Biosynthesis-Like Domain-Containing Protein; MAWD-Binding Protein; MAWDBP; Unknown Protein 32 From 2D-PAGE of Liver Tissue; PBLD; MAWBP
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Species
Human
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P30039-1
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Expression Region
M1-A288
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AA Sequence
MKLPIFIADAFTARAFRGNPAAVCLLENELDEDMHQKIAREMNLSETAFIRKLHPTDNFAQSSCFGLRWFTPASEVPLCGHATLASAAVLFHKIKNMNSTLTFVTLSGELRARRAEDGIVLDLPLYPAHPQDFHEVEDLIKTAIGNTLVQDICYSPDTQKLLVRLSDVYNRSFLENLKVNTENLLQVENTGKVKGLILTLKGEPGGQTQAFDFYSRYFAPWVGVAEDPVTGSAHAVLSSYWSQHLGKKEMHAFQCSHRGGELGISLRPDGRVDIRGGAAVVLEGTLTA
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Protein Length
Full Length of Isoform-1
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Molecular Weight
30 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PBLD, or Protein Disulfide Isomerase-like Domain Containing protein, is gaining attention in the fields of biochemistry and molecular biology due to its role in protein folding and the formation of disulfide bonds within the endoplasmic reticulum. This protein is primarily involved in the maturation of secretory proteins, which is crucial for cellular homeostasis and function. Dysregulation of PBLD has been implicated in various diseases, including cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. Recent advances in recombinant protein technology have enabled the production of PBLD in sufficient quantities for detailed functional studies and structural characterization. These studies are essential for elucidating the mechanistic pathways through which PBLD operates, opening avenues for drug development and disease intervention. Moreover, understanding the molecular dynamics of PBLD can provide insights into the broader implications of protein misfolding and aggregation in various pathological contexts. As such, research into PBLD serves not only to advance our basic understanding of protein biochemistry but also to potentially translate into clinical applications aimed at mitigating the effects of related diseases.
