Analytical Data
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Gene name
NOX3
- Application
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Alternative Names
GP91-3; MOX-2; NADPH Oxidase 3; Mitogenic oxidase 2; gp91phox homolog 3
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Species
Rat
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q672K1
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Expression Region
Gly221~Gln466
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Molecular Weight
31kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NOX3, a member of the NADPH oxidase family, is primarily expressed in the inner ear and plays a critical role in the development and function of auditory and balance systems. Its encoded protein is involved in the generation of reactive oxygen species (ROS), which are essential for cellular signaling processes. Dysfunction or dysregulation of NOX3 has been implicated in various auditory disorders, including hearing loss and vestibular dysfunction. Recent studies have highlighted the importance of NOX3 in cellular responses to oxidative stress and its potential contribution to age-related auditory decline. The recombinant expression of NOX3 protein provides a powerful tool for investigating its biochemical properties, interaction with other cellular components, and the mechanisms underlying ROS production. This research not only enhances our understanding of NOX3's physiological roles but also opens pathways for therapeutic strategies aimed at mitigating auditory impairments associated with its dysfunction. With advancements in recombinant protein technology, further exploration of NOX3 offers promising prospects for elucidating its contributions to both health and disease within the auditory system.
