Analytical Data
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Gene name
POLR3C
- Application
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Alternative Names
DNA-directed RNA polymerase III subunit CRNA polymerase III 62KDA subunit ;RPC62
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BUI4
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Expression Region
1-534aa
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Molecular Weight
76.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
POLR3C, a subunit of the RNA polymerase III complex, plays a critical role in the transcription of small RNAs, including tRNAs, 5S rRNA, and other non-coding RNAs. This enzyme complex is essential for various cellular processes, such as gene expression regulation, cell proliferation, and response to stress. Research on POLR3C has gained significant attention due to its involvement in several human diseases, including autoimmune disorders and certain types of cancers. The recruitment of POLR3C to specific gene promoters is tightly regulated and can influence cellular response pathways. Additionally, alterations in POLR3C function may disrupt normal cellular homeostasis and contribute to disease pathogenesis. Given the increasing recognition of the importance of non-coding RNAs in cellular functions and disease mechanisms, understanding POLR3C's structure, function, and regulatory mechanisms is vital. Recent studies have focused on protein structure characterization and potential therapeutic targets for conditions associated with POLR3C dysregulation. Insights gained from this research may pave the way for novel interventions in related diseases, highlighting the significance of POLR3C in both fundamental biology and clinical applications.
