Analytical Data
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Gene name
MR
- Application
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Alternative Names
NR3C2; MLR; MCR; Aldosterone Receptor; Nuclear Receptor Subfamily 3 Group C Member 2
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P08235
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Expression Region
Val739~Lys984
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Molecular Weight
59kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of MR (mineralocorticoid receptor) recombinant proteins has gained significant attention due to their crucial role in various physiological processes, including electrolyte balance, blood pressure regulation, and inflammation. MR is a type of steroid hormone receptor that binds to mineralocorticoids, primarily aldosterone, and mediates their effects on target tissues such as the kidneys, heart, and vascular system. Dysregulation of MR signaling has been implicated in several pathological conditions, including hypertension, heart failure, and chronic kidney disease. As a result, understanding MR's structure and function is essential for identifying novel therapeutic strategies. The use of recombinant protein techniques allows researchers to produce and characterize MR in a controlled laboratory environment, facilitating the study of its ligand-binding properties, downstream signaling pathways, and potential interactions with other proteins. Furthermore, recombinant MR proteins can be used to screen for small molecules or peptides that can modulate MR activity, offering a promising avenue for drug discovery. Overall, the research on MR recombinant proteins aims to elucidate the molecular mechanisms underlying MR function and to develop targeted therapies for diseases associated with MR dysregulation.
