Analytical Data
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基因名
MR
- Application
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别名
NR3C2; MLR; MCR; Aldosterone Receptor; Nuclear Receptor Subfamily 3 Group C Member 2
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P08235
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表达区间
Val739~Lys984
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分子量
59kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of MR (mineralocorticoid receptor) recombinant proteins has gained significant attention due to their crucial role in various physiological processes, including electrolyte balance, blood pressure regulation, and inflammation. MR is a type of steroid hormone receptor that binds to mineralocorticoids, primarily aldosterone, and mediates their effects on target tissues such as the kidneys, heart, and vascular system. Dysregulation of MR signaling has been implicated in several pathological conditions, including hypertension, heart failure, and chronic kidney disease. As a result, understanding MR's structure and function is essential for identifying novel therapeutic strategies. The use of recombinant protein techniques allows researchers to produce and characterize MR in a controlled laboratory environment, facilitating the study of its ligand-binding properties, downstream signaling pathways, and potential interactions with other proteins. Furthermore, recombinant MR proteins can be used to screen for small molecules or peptides that can modulate MR activity, offering a promising avenue for drug discovery. Overall, the research on MR recombinant proteins aims to elucidate the molecular mechanisms underlying MR function and to develop targeted therapies for diseases associated with MR dysregulation.












