Analytical Data
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Gene name
GDAP2
- Application
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Alternative Names
FLJ20142; Ganglioside induced differentiation associated protein 2; Ganglioside-induced differentiation-associated protein 2; GDAP2; GDAP2_HUMAN; MACROD3
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NXN4
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Expression Region
1-496aa
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Molecular Weight
72 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GDAP2, or Ganglioside-induced Differentiation Associated Protein 2, is a key protein implicated in neuronal differentiation and function. Its role in the nervous system has garnered attention due to its association with various neurodegenerative disorders and its potential involvement in cell signaling pathways that influence neuronal health. Recent studies have revealed that GDAP2 plays a crucial role in regulating mitochondrial dynamics, which are essential for maintaining cellular energy homeostasis and preventing oxidative stress. Given that mitochondrial dysfunction is a common feature in many neurodegenerative diseases, understanding the molecular mechanisms underlying GDAP2's function could provide valuable insights into potential therapeutic targets. Furthermore, the generation of recombinant GDAP2 proteins has facilitated deeper investigations into its biochemical properties and cellular interactions, allowing researchers to explore its influence on neuronal viability and degeneration. As GDAP2 is relatively understudied compared to other proteins in the same family, continued research into its structure and function may unveil novel pathways for intervention in neurological disorders, highlighting its significance in both basic and applied biomedical research.
