Analytical Data
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Gene name
NRGN
- Application
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Alternative Names
Ng; NEUG; Protein Kinase C Substrate RC3
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92686
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Expression Region
Met1~Ala67
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Molecular Weight
15kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NRGN (Neurogranin) is a peptide predominantly expressed in the brain, particularly in the postsynaptic terminals of excitatory neurons. It plays a crucial role in various neurophysiological processes, including synaptic plasticity, memory formation, and cognitive function. Research into NRGN has gained momentum due to its potential implications in neurodegenerative diseases and psychiatric disorders. Aberrant levels of NRGN have been associated with conditions such as Alzheimer's disease, schizophrenia, and depression, leading to increased interest in its molecular mechanisms and therapeutic potential. The generation of recombinant NRGN protein enables researchers to investigate its structure-function relationships, interactions with other proteins, and its role in neuronal signaling pathways in vitro and in vivo. Furthermore, understanding the dynamics of NRGN can aid in the development of biomarker strategies for early diagnosis and intervention in neuropsychiatric disorders. By exploring the biochemical characteristics of recombinant NRGN, scientists aim to uncover novel insights into synaptic function and neurodevelopment, ultimately contributing to the advancement of treatment strategies targeting synaptic dysfunction and enhancing cognitive health.
