Analytical Data
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Gene name
TAF1
- Application
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Alternative Names
NSCL2; OF; BA2R; CCG1; CCGS; P250; TAF2A; KAT4; DYT3/TAF1; TAF1 RNA Polymerase II; Dystonia 3; TBP-associated factor 250 kDa; Cell cycle gene 1 protein
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P21675
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Expression Region
Thr1379~Pro1636
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Molecular Weight
34kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TAF1 (TATA-binding protein-associated factor 1) is a key component of the transcriptional machinery that plays a crucial role in the regulation of gene expression. As a part of the mediator complex in eukaryotic cells, TAF1 influences RNA polymerase II activity by interacting with a variety of transcription factors and co-regulators. Recent studies have highlighted its involvement not only in basic transcription processes but also in cellular responses to stress and the regulation of cell cycle progression. Mutations or dysregulation of TAF1 have been implicated in various diseases, including cancer, neurodegenerative disorders, and other genetic conditions. The interest in TAF1 recombinant proteins stems from its potential therapeutic applications and the need for a deeper understanding of its functionalities. By producing TAF1 in recombinant systems, researchers aim to investigate its structural properties, functional interactions, and the mechanisms underlying its role in transcriptional regulation. This research holds promising implications for the development of targeted therapies that could modulate TAF1 activity and influence disease outcomes, thus making TAF1 a focal point in the fields of molecular biology and therapeutic development.
