Analytical Data
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Gene name
Menin
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简介
Menin Protein is an endocrine tumor suppressor and transcriptional regulator. By binding to various transcription factors and signaling molecules, Menin Protein plays roles in activating or inhibiting gene transcription and regulating multiple signaling pathways such as TGFβ and Wnt in different tissues. Menin Protein is crucial in processes including cell growth, cell cycle, genomic stability, and bone development. Menin Protein, Human is a recombinant Menin protein expressed by E. coli without a tag[1][2][3].
- Application
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Alternative Names
MEN1; Menin
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00255-1
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Expression Region
M1-L615
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Protein Length
Full Length
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Molecular Weight
68 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Menin is a protein encoded by the MEN1 gene, which plays a crucial role in endocrine tumorigenesis associated with Multiple Endocrine Neoplasia type 1 (MEN1) syndrome. The MEN1 gene mutation leads to the development of tumors in endocrine glands, including the pituitary gland, parathyroid gland, and pancreas. As a tumor suppressor, menin is involved in various cellular processes, including proliferation, apoptosis, and differentiation, as well as the regulation of gene expression through its interactions with chromatin and transcription factors. Research on menin has expanded in recent years, focusing on its dual role in both tumor suppression and potential oncogenic pathways. Studies have explored the molecular mechanisms underlying menin function, which include its interactions with histone methyltransferases and the epigenetic regulation of gene expression. Given its central role in endocrine tumor development, menin is a promising target for therapeutic interventions, particularly in the context of MEN1 syndrome. Additionally, understanding menin's function in cellular signaling pathways could provide insights into novel treatment strategies for other malignancies. The ongoing research aims to elucidate the precise mechanisms of menin action, explore its potential as a biomarker for tumor progression, and develop menin-targeted therapies that could improve patient outcomes in MEN1-related tumors and possibly other cancers.
