Analytical Data
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基因名
CRKL
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简介
CRKL protein mediates intracellular signal transduction, interacts with tyrosine-phosphorylated EPOR and INPP5D/SHIP1, and plays a role in erythropoietin receptor and phosphoinositide signaling. It also binds to DOCK2 and DOCK5, suggesting regulation of guanine nucleotide exchange factors. CRKL Protein, Human is the recombinant human-derived CRKL protein, expressed by E. coli , with tag free.
- Application
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别名
CRKL; Crk-like protein
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P46109
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表达区间
M1-E303
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蛋白长度
Full Length
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分子量
33.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CRKL, or CRK-like protein, is a member of the CRK gene family known for its role in mediating signal transduction pathways that influence cellular processes such as proliferation, differentiation, and survival. It plays a critical role in various biological functions, including cytokine signaling and cell migration, making it a key player in both normal physiology and disease states, particularly in cancer. Recent research has highlighted CRKL's involvement in oncogenic signaling pathways, as it acts as an adapter protein interacting with several tyrosine kinases and other signaling molecules. The study of CRKL recombinant proteins is essential for elucidating its biological functions and regulatory mechanisms. By expressing and purifying CRKL in a recombinant system, researchers can investigate its interactions with other proteins, identify potential post-translational modifications, and analyze its functional roles in vitro and in vivo. Understanding the structure-function relationship of CRKL through recombinant studies can provide insights into its contribution to tumorigenesis and may lead to the identification of novel therapeutic targets for cancer treatment. As such, CRKL represents a promising avenue for research aimed at unraveling the complexities of cell signaling networks and their implications in health and disease.
