Analytical Data
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Gene name
SLC44A1
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简介
The SLC44A1 protein acts as a choline/H+ and high-affinity ethanolamine/H+ antiporter and is critical for regulating cellular choline and ethanolamine transport. Its dual function actively redistributes intracellular ethanolamine and balances the CDP-Cho and CDP-Etn arms of the Kennedy pathway. SLC44A1 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC44A1 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
- Application
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Alternative Names
SLC44A1; Choline transporter-like protein 1; CDw92; Solute carrier family 44 member 1; CD92
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Species
Human
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Source
Baculovirus
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Tag
N-MBP;C-Flag;N-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8WWI5
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Expression Region
G2-A657
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Protein Length
Full Length of Mature Protein
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Molecular Weight
117.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC44A1, a member of the solute carrier family, encodes a protein that plays a crucial role in the transport of choline and other quaternary ammonium compounds across cellular membranes. This transporter is primarily expressed in the brain, liver, and other tissues where choline uptake is essential for various physiological processes, including neurotransmitter synthesis and lipid metabolism. Recent studies have highlighted the importance of SLC44A1 in maintaining cellular homeostasis and its potential involvement in neurological disorders and metabolic diseases. Additionally, mutations in the SLC44A1 gene have been linked to conditions such as hereditary persistence of fetal hemoglobin and other hemolytic anemias, indicating its significance in red blood cell development and function. The recombinant protein expression of SLC44A1 facilitates detailed functional studies, allowing researchers to investigate its substrate specificity, transport mechanisms, and regulatory pathways. Understanding the structure and function of SLC44A1 through recombinant approaches could provide valuable insights into the pathological mechanisms underlying related diseases and aid in the development of targeted therapeutic strategies.
