Analytical Data
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Gene name
IPO8
- Application
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Alternative Names
RANBP8; RAN Binding Protein 8
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Species
Mouse
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7TMY7
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Expression Region
Tyr417~Val622
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Molecular Weight
54kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
IPO8, or Importin 8, is a member of the importin protein family, which plays a critical role in the nuclear transport of proteins and RNA. It has garnered significant attention in recent years due to its involvement in various cellular processes, including the regulation of gene expression, cell proliferation, and apoptosis. Research has shown that IPO8 can influence the transport of key regulatory proteins, thereby impacting multiple signaling pathways, such as those involved in cancer and neurodegenerative diseases. The study of IPO8 and its associated pathways is vital for understanding cellular homeostasis and may provide insights into therapeutic strategies for diseases characterized by dysregulated nuclear transport. Additionally, IPO8's role in immune response modulation has made it a target of interest in immunology and vaccine development. The reconstitution of IPO8 as a recombinant protein allows for detailed structural and functional studies, enabling researchers to dissect its precise mechanisms of action. This substrate-specific transport mechanism of IPO8 further highlights its potential as a molecular target for novel drug discovery and personalized medicine approaches, making it a prominent focus in contemporary biomedical research.
