Analytical Data
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Gene name
P371
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简介
The P371 protein is critical in cellular processes and mediates vitamin K-dependent carboxylation of glutamate residues to form calcium-binding γ-carboxyglutamic acid (Gla) residues. At the same time, it converts the reduced hydroquinone form of vitamin K into vitamin K epoxide. P371 Protein, Human (L573F, sf9, FLAG) is the recombinant human-derived P371 protein, expressed by sf9 insect cells , with C-Flag labeled tag.
- Application
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Alternative Names
GGCX; Vitamin K-dependent gamma-carboxylase; Gamma-glutamyl carboxylase; Peptidyl-glutamate 4-carboxylase; Vitamin K gamma glutamyl carboxylase
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Species
Human
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Source
Baculovirus
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Tag
C-Flag
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P38435
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Expression Region
M1-F758, L573F
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Protein Length
Full Length
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
P371 is a recombinant protein that has garnered significant interest in the fields of biochemistry and molecular biology due to its potential applications in therapeutics and diagnostics. Originally derived from a specific organism or cell line, studies indicate that P371 plays a crucial role in various biological processes, making it a target for understanding cellular mechanisms and disease pathways. The recombinant production of P371 allows for the study of its structure-function relationships, facilitating insights into its functional properties and interactions with other biomolecules. Furthermore, the ability to produce P371 in a controlled manner enhances its availability for research and experimentation, opening avenues for the development of novel treatments in areas such as cancer, infectious diseases, and metabolic disorders. Recent advancements in biotechnology have also enabled the optimization of P371's expression and purification, which is critical for extensive in vitro and in vivo studies. As researchers continue to unravel the complex interactions involving P371, its significance as a biomarker or therapeutic target is increasingly recognized, potentially leading to breakthroughs in personalized medicine and targeted therapies.
