Analytical Data
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基因名
Cardiotrophin-1/CTF1
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简介
CNTF is a pluripotent neurotrophic factor, belonging to the IL-6 cytokine family[1]. CNTF could protect retinal cone and rod photoreceptors[2]. CNTF has neuroprotective effects on a variety of central and also peripheral nervous system neurons[3]. CNTF Protein, Human (His) is produced by E. coli (A2-M200) with N-terminal His-tag.
- Application
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别名
Ciliary neurotrophic factor; CNTF
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P26441
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表达区间
A2-M200
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氨基酸序列
AFTEHSPLTPHRRDLCSRSIWLARKIRSDLTALTESYVKHQGLNKNINLDSADGMPVASTDQWSELTEAERLQENLQAYRTFHVLLARLLEDQQVHFTPTEGDFHQAIHTLLLQVAAFAYQIEELMILLEYKIPRNEADGMPINVGDGGLFEKKLWGLKVLQELSQWTVRSIHDLRFISSHQTGIPARGSHYIANNKKM
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蛋白长度
Partial
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分子量
27-30 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Cardiotrophin-1 (CT-1) is a member of the IL-6 cytokine family that plays a critical role in cardiovascular and neuroprotective functions. It is primarily expressed in the heart and various tissues, where it exerts its effects through the activation of gp130 and the IL-6 receptor complex, stimulating growth and survival of cardiomyocytes and promoting cardiac hypertrophy. The therapeutic potential of CT-1 has gained significant attention due to its involvement in cardiac remodeling, heart failure, and response to myocardial injury. Recombinant CT-1 protein has been developed for research to further understand its biological properties, signaling pathways, and potential applications in regenerative medicine. Studies using recombinant CT-1 have shown promise in enhancing cardiac repair mechanisms, offering insights into its role in promoting endothelial cell function and angiogenesis. Investigating the mechanisms by which CT-1 influences cardiac physiology may open new avenues for developing novel treatments for heart diseases and improving heart function post-injury. Overall, the continued exploration of CT-1 offers potential for therapeutic strategies aiming at enhancing cardiac resilience and addressing various cardiovascular conditions.
