Analytical Data
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基因名
LRP-5
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简介
The LRP-5 protein functions as a coreceptor, cooperating with Frizzled receptors to initiate the canonical Wnt signaling pathway. It is critical for cell fate determination and self-renewal and plays an important role in posterior ectoderm patterning during gastrulation and bone development by affecting osteoblast proliferation and differentiation. LRP-5 Protein, Human (HEK293, mFc) is the recombinant human-derived LRP-5 protein, expressed by HEK293 , with C-mFc labeled tag.
- Application
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别名
LRP-5; LRP-7; LR3; BMND1; BMND1OPTA1; EVR1; EVR4; HBM; LR3VBCH2; LRP5; LRP7; OPPG; OPS; OPTA1; VBCH2
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种属
Human
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表达系统
HEK293
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标签
C-mFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75197
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表达区间
E644-Q1263
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蛋白长度
Partial
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分子量
110-115 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LRP-5 (Low-Density Lipoprotein Receptor-Related Protein 5) is a member of the LDL receptor family and plays a crucial role in various physiological processes, including bone metabolism and the Wnt signaling pathway, which is essential for bone formation and maintenance. The study of LRP-5 has gained significant attention due to its implications in osteoporosis and bone-related diseases; mutations in the LRP-5 gene are associated with high bone mass and skeletal anomalies. Researchers are particularly interested in developing recombinant LRP-5 proteins to explore their structural and functional characteristics, facilitating the understanding of LRP-5's role in signaling pathways and gene regulation. Additionally, recombinant LRP-5 proteins can serve as valuable tools for drug development and therapeutic strategies aimed at treating metabolic bone disorders. By investigating the interactions and mechanisms of action of LRP-5 within cellular contexts, scientists aim to uncover potential targets for enhancing bone health and countering degenerative bone diseases, highlighting the importance of LRP-5 in both fundamental research and clinical applications.
