Analytical Data
-
Gene name
KIR3DL2/CD158k
-
简介
KIR3DL2/CD158k is expressed on NK and T cells and recognizes MHC class I, specifically the peptide-free open conformer of HLA-F. Binding to HLA-F negatively regulates NK and T cell effector functions, thereby complexly modulating immune responses. KIR3DL2/CD158k Protein, Human (HEK293, His-Avi) is the recombinant human-derived KIR3DL2/CD158k protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
- Application
-
Alternative Names
NKAT-4; NKAT4; CD158k; CL-5; KIR3DL2; NKAT4A; NKAT4B; p140
-
Species
Human
-
Source
HEK293
-
Tag
C-Avi;C-8*His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P43630-1
-
Expression Region
L22-L339
-
Protein Length
Extracellular Domain
-
Molecular Weight
40-70 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KIR3DL2, also known as CD158k, is an important member of the Killer Immunoglobulin-like Receptor (KIR) family, which plays a critical role in the regulation of natural killer (NK) cell activity and the immune response. It is primarily expressed on specific subsets of NK cells and is involved in recognizing and responding to human leukocyte antigen (HLA) class I molecules, particularly those presenting viral or tumor-associated antigens. Studies have shown that KIR3DL2 is associated with various diseases, including viral infections like HIV and certain cancers, making it a crucial target for immunological research. The recombinant protein of KIR3DL2/CD158k has been developed for several purposes, including studying the receptor's function, exploring its ligand interactions, and evaluating its potential as a therapeutic target. Understanding the structure and dynamics of this receptor through recombinant protein studies can provide insights into its role in immune evasion by tumors and viruses, and facilitate the design of novel immunotherapies aimed at enhancing NK cell responses. Researchers are particularly interested in how KIR3DL2/CD158k contributes to the balance between activating and inhibiting signals in NK cells, which is essential for maintaining immune homeostasis and developing effective immune-based treatments.
