Analytical Data
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基因名
KIR3DL2/CD158k
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简介
KIR3DL2/CD158k is expressed on NK and T cells and recognizes MHC class I, specifically the peptide-free open conformer of HLA-F. Binding to HLA-F negatively regulates NK and T cell effector functions, thereby complexly modulating immune responses. KIR3DL2/CD158k Protein, Human (HEK293, His-Avi) is the recombinant human-derived KIR3DL2/CD158k protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
- Application
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别名
NKAT-4; NKAT4; CD158k; CL-5; KIR3DL2; NKAT4A; NKAT4B; p140
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种属
Human
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表达系统
HEK293
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标签
C-Avi;C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P43630-1
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表达区间
L22-L339
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蛋白长度
Extracellular Domain
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分子量
40-70 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KIR3DL2, also known as CD158k, is an important member of the Killer Immunoglobulin-like Receptor (KIR) family, which plays a critical role in the regulation of natural killer (NK) cell activity and the immune response. It is primarily expressed on specific subsets of NK cells and is involved in recognizing and responding to human leukocyte antigen (HLA) class I molecules, particularly those presenting viral or tumor-associated antigens. Studies have shown that KIR3DL2 is associated with various diseases, including viral infections like HIV and certain cancers, making it a crucial target for immunological research. The recombinant protein of KIR3DL2/CD158k has been developed for several purposes, including studying the receptor's function, exploring its ligand interactions, and evaluating its potential as a therapeutic target. Understanding the structure and dynamics of this receptor through recombinant protein studies can provide insights into its role in immune evasion by tumors and viruses, and facilitate the design of novel immunotherapies aimed at enhancing NK cell responses. Researchers are particularly interested in how KIR3DL2/CD158k contributes to the balance between activating and inhibiting signals in NK cells, which is essential for maintaining immune homeostasis and developing effective immune-based treatments.
