Analytical Data
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Gene name
TMEM106B
- Application
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Species
Mouse
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Source
Yeast
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Tag
C- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q80X71
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Expression Region
119-275aa
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Molecular Weight
19.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TMEM106B (Transmembrane Protein 106B) is a protein that has garnered significant interest in the fields of neurobiology and genetics, particularly for its association with neurodegenerative diseases such as frontotemporal lobar degeneration (FTLD) and Alzheimer's disease. Research indicates that TMEM106B plays a crucial role in lysosomal function and intracellular trafficking, influencing the processing of various proteins and the degradation of cellular debris. Genetic variants of TMEM106B have been identified as risk factors for these neurodegenerative conditions, suggesting that alterations in its expression or function could contribute to the pathogenesis of these diseases. Consequently, the study of recombinant TMEM106B protein is essential for understanding its structure-function relationships and the mechanisms by which it affects neurodegenerative processes. By producing and characterizing recombinant TMEM106B, researchers aim to delineate its molecular interactions and potential therapeutic targets, ultimately facilitating the development of novel strategies to mitigate the progression of neurodegeneration. The ongoing investigation into TMEM106B is vital not only for elucidating its role in diseases but also for advancing our understanding of lysosomal biology and its relevance to neuronal health.
