Recombinant Human HLA-E*01:03&B2M&Peptide(VMAPRTLVL) Tetramer Protein (HEK293)，Avi & His

HLA-E*01:03, in conjunction with β2-microglobulin (B2M) and the specific peptide VMAPRTLVL, is a significant focus in immunological research, particularly in the context of modulating immune responses and understanding presentations of non-classical MHC molecules. HLA-E serves as a vital player in immune regulation, as it presents peptides derived from highly conserved leader sequences of other MHC class I molecules to CD94/NKG2 receptors on natural killer (NK) cells and some T cells. The engagement between HLA-E and these receptors plays a crucial role in preventing the activation of NK cells against healthy cells, thereby contributing to immune tolerance and the maintenance of self-integrity. The tetramer format, combining HLA-E*01:03 with B2M and the peptide VMAPRTLVL, allows for the specific visualization and analysis of HLA-E-restricted T cell responses. By presenting this complex, researchers can better understand how certain peptides influence T cell recognition, which can be pivotal in cancer immunotherapy and viral infections where immune evasion is a concern. This research could further elucidate the mechanisms of immune response, potentially leading to innovative therapeutic strategies that harness or manipulate T cell activity against tumors or chronic infections. The development and characterization of the HLA-E*01:03/B2M/VMAPRTLVL tetramer thus provide a crucial tool for studying the implications of HLA-E in health and disease.