Analytical Data
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Gene name
CCDC47
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简介
The CCDC47 protein is an important component of the multichannel translocon (MPT) complex and cooperates with SEC61 to mediate the insertion of multichannel membrane proteins. As part of the PAT subcomplex within MPT, CCDC47 helps sequester polar regions within the transmembrane domain, ensuring correct membrane protein assembly. CCDC47 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CCDC47 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
PAT complex subunit CCDC47; Calumin; Adipocyte-specific protein 4; Asp4
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Species
Mouse
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q9D024
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Expression Region
K21-S135
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Protein Length
Cytoplasmic Domain
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Molecular Weight
20-23 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCDC47 (Coiled-Coil Domain Containing 47) is a protein that has garnered attention in recent years due to its potential roles in various biological processes, particularly in the context of cellular function and regulation. Initially identified as a gene associated with cellular stress responses, CCDC47 has been implicated in important cellular pathways such as cell proliferation, differentiation, and apoptosis. Its coiled-coil domain structure suggests potential interactions with other proteins, making it a candidate for involvement in complex protein networks. Research has indicated that CCDC47 may play a significant role in diseases, including cancer, where altered expression levels have been reported. The study of recombinant CCDC47 protein aims to elucidate its functional properties, mechanisms of action, and interaction partners, which could provide insights into its biological significance. By generating recombinant CCDC47, researchers hope to investigate its structural characteristics and functional roles in vitro, paving the way for potential therapeutic applications and a deeper understanding of its contribution to disease pathology. This research could ultimately lead to novel strategies for targeting CCDC47 in disease contexts, particularly in malignancies where its expression is dysregulated. As interest in CCDC47 continues to grow, further investigations into its biological implications and the molecular mechanisms underlying its functions remain crucial for advancing our knowledge in cellular biology and disease mechanisms.
