Analytical Data
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Gene name
Vanin-1
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简介
Vanin-1 Proteinas, as an amidohydrolase, specifically targets D-pantetheine's carboamide linkage, crucial for recycling pantothenic acid and releasing cysteamine. Its enzymatic breakdown of D-pantetheine underscores its significance in vitamin B5 recycling and cysteamine liberation metabolic processes. Vanin-1 Protein, Human (HEK293, His) is the recombinant human-derived Vanin-1 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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Alternative Names
Pantetheinase; Pantetheine Hydrolase; Tiff66; Vascular Non-Inflammatory Molecule 1; Vanin-1; VNN1
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
O95497
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Expression Region
Q22-S490
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AA Sequence
QDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDILEGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPCNNRNRFGQTPVQERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQNLFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMNVLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLLLSQLDSHPSHSAVVNWTSYASSIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKDLCCHLSYKMSENIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETASTRFEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLYEKDWASNASS
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Protein Length
Partial
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Molecular Weight
70-90 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Vanin-1 is a member of the vasculature-associated neural protein family and plays a crucial role in various physiological and pathological processes. This protein is primarily recognized for its function in the NAD+-dependent deacetylation of proteins and is involved in cellular responses to oxidative stress, inflammation, and tissue repair. Research has indicated that Vanin-1 is expressed in various tissues and is particularly significant in immune responses, where it regulates the activation and migration of immune cells. Dysregulation of Vanin-1 has been associated with several diseases, including cancer, diabetes, and neurodegenerative disorders, highlighting its potential as a therapeutic target. Given its multifaceted role, the production of recombinant Vanin-1 protein is essential for elucidating its biological functions and interactions. The recombinant protein facilitates detailed studies into the mechanisms by which Vanin-1 influences cellular behavior and contributes to disease pathology, making it a valuable tool for both basic and translational research. Understanding the structure-function relationship of Vanin-1 through recombinant protein studies could pave the way for novel therapeutic strategies aimed at modulating its activity in disease contexts. Overall, the study of Vanin-1 recombinant protein is pertinent for advancing our knowledge of immune modulation and inflammation, which may ultimately lead to innovative treatment approaches.
