Cat: IPD-X26101

Recombinant Human TM2D1 Protein (HEK293),mFc

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Analytical Data

  • Gene name

    TM2D1

  • 简介

    The TM2D1 protein may be involved in amyloid beta-induced apoptosis by interacting with beta-APP42, especially amyloid beta protein 42 (APP beta-APP42). This suggests a role in molecular pathways associated with amyloid-induced cell death. TM2D1 Protein, Human (HEK293, Fc) is the recombinant human-derived TM2D1 protein, expressed by HEK293 , with C-mFc labeled tag.

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    TM2 domain-containing protein 1; Amyloid-beta-binding protein; hBBP; BBP

  • Species

    Human

  • Source

    HEK293

  • Tag

    C-mFc

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q9BX74

  • Expression Region

    T38-G118

  • Protein Length

    Partial

  • Molecular Weight

    45-60 kDa band in SDS-PAGE under reducing conditions.

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

TM2D1, a member of the transmembrane (TM) domain family, is involved in various physiological processes, including cell signaling and membrane dynamics. Its role in cellular functions has garnered interest in both basic and applied research. The protein's unique structure, characterized by multiple transmembrane domains, suggests potential interactions with membrane lipids and other membrane proteins, which are crucial for maintaining cellular integrity and communication. Studies have indicated that TM2D1 may be implicated in specific diseases, underscoring its potential as a biomarker or therapeutic target. The need for detailed understanding of TM2D1's structure-function relationship has spurred research into its biochemical properties and interactions. Current methodologies, including recombinant protein expression and purification, enable the characterization of TM2D1's functional role at the molecular level. Additionally, insights into its signaling pathways may reveal novel mechanisms underlying various pathologies, paving the way for innovative therapeutic strategies. Exploring TM2D1's biological significance and potential applications in medicine is a priority for advancing knowledge in cell biology and molecular medicine.

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