Analytical Data
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Gene name
NAA10/ARD1
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简介
The NAA10/ARD1 protein is the catalytic subunit of the N-terminal acetyltransferase complex and has alpha acetyltransferase activity. NAA10/ARD1 affects vascular, hematopoietic, and neuronal growth and development. NAA10/ARD1 inhibits tumor cell migration, inhibits mTOR activity and cancer development. NAA10/ARD1 Protein, Human (sf9) is the recombinant human-derived NAA10/ARD1 protein, expressed by Sf9 insect cells , with tag free.
- Application
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Alternative Names
N-alpha-acetyltransferase 10; hARD1; NatA catalytic subunit Naa10; ARD1; ARD1A; TE2
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Species
Human
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Source
Baculovirus
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P41227
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Expression Region
M1-S235
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Protein Length
Full Length
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Molecular Weight
27 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NAA10, also known as ARD1 (N-alpha-acetyltransferase 10), is a pivotal enzyme involved in the post-translational modification of proteins through N-terminal acetylation, a process that influences protein stability, localization, and function. This enzyme is part of the Nα-acetyltransferase family, which has gained attention in recent years due to its significant role in various cellular processes and its implications in human diseases. Research indicates that dysregulation of NAA10/ARD1 activity can be associated with cancer, neurodegenerative disorders, and other pathologies, making it a potential target for therapeutic intervention. Furthermore, investigations into the structure and function of NAA10/ARD1 have advanced our understanding of its enzymatic mechanisms and substrate specificities. The identification of its substrates and interactions with other cellular components is critical to elucidating its biological functions. Additionally, recombinant forms of NAA10/ARD1 are being developed to study its biochemical properties in vitro, providing further insights into its role in cellular regulation and its potential as a drug target. Overall, the study of NAA10/ARD1 is crucial for understanding the broader implications of protein acetylation in health and disease.
