Analytical Data
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基因名
Gamma-enolase/Enolase 2
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简介
Gamma-enolase/Enolase 2 protein exhibits neurotrophic and neuroprotective properties, binding to neocortical neurons and promoting cell survival through a calcium-dependent mechanism. This suggests its potential role in supporting neuron viability within the central nervous system. Gamma-enolase/Enolase 2 Protein, Human (His) is the recombinant human-derived Gamma-enolase/Enolase 2 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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别名
rHuGamma-enolase/ENO2, His; Gamma-enolase; 2-phospho-D-glycerate hydro-lyase; Enolase 2; Neural enolase; Neuron-specific enolase; NSE; ENO2
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P09104-1
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表达区间
M1-L434
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氨基酸序列
MSIEKIWAREILDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDGDKQRYLGKGVLKAVDHINSTIAPALISSGLSVVEQEKLDNLMLELDGTENKSKFGANAILGVSLAVCKAGAAERELPLYRHIAQLAGNSDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGAESFRDAMRLGAEVYHTLKGVIKDKYGKDATNVGDEGGFAPNILENSEALELVKEAIDKAGYTEKIVIGMDVAASEFYRDGKYDLDFKSPTDPSRYITGDQLGALYQDFVRDYPVVSIEDPFDQDDWAAWSKFTANVGIQIVGDDLTVTNPKRIERAVEEKACNCLLLKVNQIGSVTEAIQACKLAQENGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEELGDEARFAGHNFRNPSVL
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蛋白长度
Full Length of Isoform-1
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分子量
60 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Gamma-enolase, also known as Enolase 2, is a glycolytic enzyme that plays a crucial role in the conversion of 2-phosphoglycerate to phosphoenolpyruvate, a key step in cellular energy metabolism. Beyond its enzymatic function, gamma-enolase has garnered attention due to its involvement in various biological processes, including neuron development, apoptosis, and cellular stress responses. Research has indicated that gamma-enolase is expressed in both neuronal and non-neuronal tissues, and its aberrant expression has been linked to neurological disorders and cancer. The recombinant production of gamma-enolase allows for detailed structural and functional analysis, providing insight into its multifaceted roles in cellular physiology and disease. Moreover, recombinant gamma-enolase serves as a potential biomarker for specific cancers and neurological conditions, thus emphasizing its clinical relevance. The ongoing research aims to elucidate the precise mechanisms of gamma-enolase in disease contexts and its potential as a therapeutic target, making it a focal point for studies in biochemistry, neurobiology, and oncology.
