Analytical Data
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基因名
Kallikrein-6
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简介
Kallikrein-6 is a serine protease that exhibits substrate preference and activity against different substrates. It degrades alpha-synuclein, plays a role in synucleinopathies, and may regulate axonal growth after spinal cord injury. Kallikrein-6 Protein, Human (HEK293, His) is the recombinant human-derived Kallikrein-6 protein, expressed by HEK 293 , with C-6*His labeled tag.
- Application
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别名
Kallikrein-6; Neurosin; Protease M; SP59; Serine Protease 18; Serine Protease 9; Zyme; KLK6; PRSS18; PRSS9
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92876-1
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表达区间
E17-K244
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氨基酸序列
EEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTAAHCKKPNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSELIQPLPLERDCSANTTSCHILGWGKTADGDFPDTIQCAYIHLVSREECEHAYPGQITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQKTIQAK
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蛋白长度
Full Length of Isoform-1 Mature Protein
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分子量
33&21.63&9.72 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Kallikrein-6 (KLK6) is a member of the kallikrein-related peptidase family, which is known to play crucial roles in various physiological processes, including tissue homeostasis, inflammation, and neurodegeneration. Research has indicated that KLK6 is overexpressed in several types of cancers, especially in ovarian and prostate cancers, making it a potential biomarker for early detection and a target for therapeutic intervention. The enzyme is also involved in neurodegenerative diseases such as Alzheimer's, where it may affect amyloid precursor protein processing and tau phosphorylation, contributing to the pathogenesis of these conditions. Its multifunctional properties, including proteolytic activity, have spurred interest in developing KLK6 as a therapeutic target and diagnostic tool. Recombinant KLK6 proteins have been produced to facilitate studies on its biological functions, mechanisms of action, and interactions with other molecules. Understanding KLK6's role in disease processes could lead to novel approaches in diagnosis and treatment. As such, the study of KLK6 recombinant proteins is gaining momentum, aiming to unlock the therapeutic potential and clarify the enzyme's involvement in various pathological conditions.
