Analytical Data
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Gene name
CPLX3
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简介
CPLX3 protein is a complex protein that regulates synaptic vesicle fusion through the SNARE protein complex. CPLX3 Protein, Human (HEK293, His) is the recombinant human-derived CPLX3 protein, expressed by HEK293 , with N-His labeled tag.
- Application
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Alternative Names
Complexin-3; Complexin III; CPX III
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Species
Human
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Source
HEK293
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Tag
N-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q8WVH0
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Expression Region
M1-K154
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Protein Length
Partial
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Molecular Weight
27-33 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CPLX3, or Complexin 3, is a member of the complexin family of proteins that play a critical role in synaptic transmission and neurotransmitter release. Located in the pre-synaptic neuron, CPLX3 is known to facilitate neurotransmitter release by binding to SNARE complexes, which are essential for vesicle fusion with the plasma membrane. Its involvement in synaptic modulation contributes to the dynamics of synaptic activity and plasticity, making it vital for processes like learning and memory. Research into CPLX3 has gained traction due to its potential implications in neurodegenerative diseases and psychiatric disorders, where alterations in synaptic transmission are often observed. By studying the structure and function of CPLX3, researchers aim to unravel its specific mechanisms in synaptic communication and explore how dysregulation of this protein may contribute to neurological conditions. Additionally, because of its role in exocytosis, CPLX3 may provide a target for therapeutic strategies aimed at restoring normal synaptic function in diseases characterized by synaptic dysfunction. As such, understanding CPLX3 and its interactions with other synaptic proteins is increasingly important in the context of neuroscience research, with the potential to advance our knowledge of synaptic health and inform the development of new treatments for various neuropsychiatric conditions.
