Analytical Data
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基因名
COPZ1
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简介
The COPZ1 protein is a key coating subunit essential for intracellular protein transport.In coat isoform complexes, it binds to a dilysine motif that facilitates reversible association with Golgi vesicles.COPZ1 Protein, Human/Mouse/Rat (His) is the recombinant COPZ1 protein, expressed by E.coli , with N-His labeled tag.
- Application
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别名
Coatomer subunit zeta-1; Zeta-1-coat protein; Zeta-1 COP; COPZ; CGI-120
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种属
Rat; Mouse
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P61923
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表达区间
M1-R177
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蛋白长度
Full Length
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分子量
22.4 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COPZ1 (coat protein complex I, subunit zeta 1) is an essential component of the COPI coatomer complex, which plays a critical role in intracellular trafficking and protein sorting within the cell. This protein is involved in the retrograde transport of proteins from the Golgi apparatus back to the endoplasmic reticulum, contributing to the maintenance of organelle function and cellular homeostasis. Studies have indicated that COPZ1 is implicated in various cellular processes, including membrane dynamics, protein degradation, and the regulation of immune responses. Additionally, dysregulation of COPZ1 has been linked to several pathological conditions, including neurodegenerative diseases and cancer, highlighting its potential as a therapeutic target. The production and analysis of recombinant COPZ1 protein facilitate a deeper understanding of its structure, function, and interactions within the COPI complex, paving the way for potential biomedical applications. Recent advances in recombinant DNA technology and protein expression systems have made it possible to obtain high yields of functional COPZ1 protein, allowing researchers to investigate its biochemical properties and role in cellular mechanisms, thus contributing to the broader field of molecular and cellular biology.
