Analytical Data
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Gene name
ACSS2
- Application
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Alternative Names
ACS; ACAS2; ACSA; AceCS; MYH7B; Acetyl-Coenzyme A Synthetase 2(ADP Forming); Acyl-activating enzyme
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9QXG4
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Expression Region
Pro492~Gln701
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Molecular Weight
31kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ACSS2 (Acetyl-CoA synthetase 2) is an essential enzyme involved in cellular metabolism, particularly in the conversion of acetate into acetyl-CoA, a critical substrate for various metabolic pathways, including fatty acid synthesis and the TCA cycle. Research into ACSS2 has gained attention due to its role in regulating energy homeostasis and its implications for various diseases, including cancer and metabolic disorders. Recent studies have shown that ACSS2 expression is often upregulated in tumor cells, contributing to the increased demand for acetyl-CoA in rapidly proliferating tissues. This makes ACSS2 a potential biomarker for cancer and a target for therapeutic interventions. Furthermore, understanding the regulatory mechanisms and functional properties of ACSS2 can provide insights into metabolic reprogramming in cancer, as well as potential applications in metabolic engineering and synthetic biology. Consequently, investigating the recombinant expression of ACSS2 protein allows for detailed structural and functional analyses that could elucidate its enzymatic mechanisms, interactions with metabolites, and regulatory pathways, offering a pathway to novel therapeutic strategies in targeting metabolic aberrations. Such studies have the potential to significantly advance our understanding of cellular metabolism and its implications for health and disease.
