Analytical Data
-
基因名
HIST2H2BE
-
简介
The HIST2H2BE protein is a core component of nucleosomes, key structures in chromatin organization that wrap and compact DNA, controlling its accessibility to cellular machinery based on DNA templates. This integral role of histones, including HIST2H2BE, extends to transcriptional regulation, DNA repair, DNA replication, and chromosomal stability. HIST2H2BE Protein, Human is the recombinant human-derived HIST2H2BE protein, expressed by E. coli , with tag free.
- Application
-
别名
Histone H2B type 2-E; Histone H2B-GL105; H2B/q; H2BC21; H2BFQ
-
种属
Human
-
表达系统
E. coli
-
标签
Tag Free
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q16778
-
表达区间
M1-K126
-
蛋白长度
Full Length
-
分子量
16 kDa.
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HIST2H2BE, a member of the histone H2B family, plays a crucial role in the packaging of DNA into chromatin, thus influencing gene expression and cellular processes. As a highly conserved protein, it is essential for maintaining chromatin structure and stability, which in turn affects various biological functions, including DNA replication, repair, and transcription. Recent research has highlighted the significance of histone variants like HIST2H2BE in epigenetic regulation, with implications for development, cellular differentiation, and disease states such as cancer. The study of HIST2H2BE and its reconstituted versions provides valuable insights into the dynamics of chromatin and allows for the exploration of post-translational modifications that regulate histone function. Understanding the functional properties of HIST2H2BE is critical for elucidating its role in the epigenetic landscape and for developing potential therapeutic strategies targeting chromatin-related disorders. The production of recombinant HIST2H2BE proteins facilitates a deeper investigation into their biochemical properties, interactions with other histones, and effects on chromatin organization and gene regulation, which can advance our understanding of fundamental cellular mechanisms.
