Analytical Data
-
基因名
CREB3L1
-
简介
CREB3L1 protein is located on the endoplasmic reticulum membrane and is converted into a transcription factor processing cyclic AMP response element binding protein 3-like protein 1. During endoplasmic reticulum stress or DNA damage, it translocates to the Golgi apparatus, is cleaved by S1P/MBTPS1 and S2P/MBTPS2, and releases a cytoplasmic domain that activates gene transcription in the nucleus. CREB3L1 Protein, Human (HEK293, His) is the recombinant human-derived CREB3L1 protein, expressed by HEK293 , with C-His labeled tag.
- Application
-
别名
Cyclic AMP-responsive element-binding protein 3-like protein 1; OASIS
-
种属
Human
-
表达系统
HEK293
-
标签
C-His
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q96BA8-1
-
表达区间
E396-S519
-
蛋白长度
Lumenal Domain
-
分子量
21-31 kDa.
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CREB3L1, also known as Luman or cAMP-responsive element-binding protein 3-like 1, is a member of the CREB/ATF family of transcription factors. It plays a crucial role in the regulation of cellular responses to stress and is particularly involved in the unfolded protein response (UPR), which is critical for maintaining endoplasmic reticulum (ER) homeostasis. Dysregulation of CREB3L1 has been implicated in various pathological conditions, including neurodegenerative diseases, metabolic disorders, and cancers. The protein is known to be activated in response to ER stress, leading to the transcription of target genes that help alleviate protein misfolding. Recent studies have highlighted the importance of CREB3L1 in cellular adaptive mechanisms, making it a potential therapeutic target for diseases characterized by ER stress. However, to fully understand its biological functions and regulatory mechanisms, further research is needed on the structure-function relationship of CREB3L1, along with its signaling pathways and interaction partners. Thus, the study of recombinant CREB3L1 protein is essential for elucidating its role in cellular stress responses and for exploring its potential implications in disease treatment strategies.
