Analytical Data
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Gene name
CREB3L1
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简介
CREB3L1 protein is located on the endoplasmic reticulum membrane and is converted into a transcription factor processing cyclic AMP response element binding protein 3-like protein 1. During endoplasmic reticulum stress or DNA damage, it translocates to the Golgi apparatus, is cleaved by S1P/MBTPS1 and S2P/MBTPS2, and releases a cytoplasmic domain that activates gene transcription in the nucleus. CREB3L1 Protein, Human (HEK293, His) is the recombinant human-derived CREB3L1 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Cyclic AMP-responsive element-binding protein 3-like protein 1; OASIS
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Species
Human
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96BA8-1
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Expression Region
E396-S519
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Protein Length
Lumenal Domain
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Molecular Weight
21-31 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CREB3L1, also known as Luman or cAMP-responsive element-binding protein 3-like 1, is a member of the CREB/ATF family of transcription factors. It plays a crucial role in the regulation of cellular responses to stress and is particularly involved in the unfolded protein response (UPR), which is critical for maintaining endoplasmic reticulum (ER) homeostasis. Dysregulation of CREB3L1 has been implicated in various pathological conditions, including neurodegenerative diseases, metabolic disorders, and cancers. The protein is known to be activated in response to ER stress, leading to the transcription of target genes that help alleviate protein misfolding. Recent studies have highlighted the importance of CREB3L1 in cellular adaptive mechanisms, making it a potential therapeutic target for diseases characterized by ER stress. However, to fully understand its biological functions and regulatory mechanisms, further research is needed on the structure-function relationship of CREB3L1, along with its signaling pathways and interaction partners. Thus, the study of recombinant CREB3L1 protein is essential for elucidating its role in cellular stress responses and for exploring its potential implications in disease treatment strategies.
