Analytical Data
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基因名
RUVBL1
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简介
The RUVBL1 protein has DNA-stimulated ATPase and DNA helicase activities and can hexamerize for ATP hydrolysis. It is a member of the NuA4 complex and contributes to histone acetylation to activate genes. RUVBL1 Protein, Human (sf9, His) is the recombinant human-derived RUVBL1 protein, expressed by Sf9 insect cells , with N-His labeled tag.
- Application
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别名
RuvB-like 1; ECP-54; NMP 238; Pontin 52; TIP49a; TAP54-alpha; RUVBL1; INO80H
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种属
Human
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表达系统
Baculovirus
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y265
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表达区间
M1-K456
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蛋白长度
Full Length
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分子量
57 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RUVBL1, a member of the RUVBL/RUVBL1/2 family of ATP-dependent helicases, plays a pivotal role in various cellular processes, including transcription regulation, DNA repair, and chromatin remodeling. Its involvement in critical biological functions has positioned RUVBL1 as a significant player in cancer biology and other diseases. Elevated expressions of RUVBL1 have been observed in multiple cancer types, suggesting its function in promoting cell proliferation and survival, making it a potential therapeutic target. Research has indicated that RUVBL1 interacts with several key protein complexes, influencing pathways that regulate cell cycle progression and apoptosis. Additionally, RUVBL1 has been implicated in the maintenance of cellular homeostasis under stress conditions, revealing its potential role in oncogenesis. Recent studies employing recombinant protein techniques have aimed to elucidate RUVBL1's structural properties, functional dynamics, and interaction networks, providing insights into its mechanisms of action. Understanding these aspects is crucial for developing targeted therapies that could disrupt its function in cancer cells and contribute to more effective treatment strategies. Consequently, the recombinant expression and characterization of RUVBL1 not only advance our knowledge of its biological roles but also underscore its potential as a target for innovative cancer therapies.
