Analytical Data
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基因名
HTRA2/OMI
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简介
HTRA2/OMI, a serine protease, crucially induces cell death via multiple mechanisms.It directly inhibits BIRC proteins, intensifying caspase activity, and can also induce cell death through a BIRC-independent, caspase-independent pathway, relying on its serine protease activity.Additionally, during apoptosis, it cleaves THAP5, promoting its degradation.Notably, isoform 2 lacks apparent proteolytic activity.HTRA2/OMI Protein, Human (His) is the recombinant human-derived HTRA2/OMI protein, expressed by E.coli , with C-His labeled tag.
- Application
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别名
Serine protease HTRA2; Serine proteinase OMI; OMI; PRSS25
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种属
Human
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表达系统
E. coli
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43464
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表达区间
A134-E458
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蛋白长度
Full Length of Mature Protein
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分子量
36.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HTRA2, also known as OMI, is a mitochondrial serine protease that plays a crucial role in various cellular processes, including apoptosis and stress response. As a member of the high-temperature requirement A (HTRA) family of proteins, HTRA2/OMI is primarily located in the mitochondria and is involved in the regulation of cellular homeostasis. Dysregulation of HTRA2/OMI has been implicated in several diseases, including neurodegenerative disorders such as Parkinson's disease and cancer, where it contributes to cell survival and death pathways. Research has focused on understanding the structure and function of the HTRA2/OMI protein, as well as its interactions with substrates and other cellular components. Insights into its proteolytic activity and regulatory mechanisms have opened potential therapeutic avenues, making HTRA2/OMI a target of interest for drug development. The recombinant expression of HTRA2/OMI in heterologous systems allows for the investigation of its functional properties and interaction dynamics, providing a foundation for exploring its role in mitochondrial function and disease. Overall, the study of HTRA2/OMI is essential for elucidating mitochondrial biology and developing strategies to counteract its associated pathologies.
