Analytical Data
-
Gene name
AHSP
-
简介
AHSP proteins are chaperones in developing red blood cells that protect alpha-hemoglobin from harmful aggregation and precipitation. It is essential for alpha-hemoglobin stability, and it regulates conditions associated with excess alpha-hemoglobin, such as beta-thalassemia. AHSP Protein, Human is the recombinant human-derived AHSP protein, expressed by E. coli , with tag free.
- Application
-
Alternative Names
Alpha-hemoglobin-stabilizing protein; Erythroid-associated factor; AHSP; EDRF; ERAF
-
Species
Human
-
Source
E. coli
-
Tag
Tag Free
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9NZD4
-
Expression Region
M1-S102
-
Protein Length
Full Length
-
Molecular Weight
12 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Antihypertensive sodium-proton exchanger (AHSP) proteins have garnered significant interest in the field of cardiovascular research due to their crucial role in regulating blood pressure and electrolyte balance. Originally identified as key players in cardiac and vascular function, AHSPs modulate sodium and hydrogen ion transport across cell membranes, impacting cellular homeostasis and overall cardiovascular health. Dysregulation of AHSP expression and function has been linked to various hypertensive disorders and heart diseases, highlighting their potential as therapeutic targets. Recent advances in protein engineering and recombinant DNA technology have enabled the production of recombinant AHSP proteins, facilitating in-depth studies of their structure-function relationships and physiological roles. Researchers are increasingly utilizing these recombinant proteins to investigate their mechanisms of action within cellular systems and animal models, aiming to elucidate how AHSPs contribute to hypertension and its associated pathologies. This growing body of research underscores the importance of AHSP proteins in cardiovascular health and paves the way for the development of novel interventions aimed at managing hypertension and improving patient outcomes.
