Analytical Data
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基因名
AHSP
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简介
AHSP proteins are chaperones in developing red blood cells that protect alpha-hemoglobin from harmful aggregation and precipitation. It is essential for alpha-hemoglobin stability, and it regulates conditions associated with excess alpha-hemoglobin, such as beta-thalassemia. AHSP Protein, Human is the recombinant human-derived AHSP protein, expressed by E. coli , with tag free.
- Application
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别名
Alpha-hemoglobin-stabilizing protein; Erythroid-associated factor; AHSP; EDRF; ERAF
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NZD4
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表达区间
M1-S102
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蛋白长度
Full Length
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分子量
12 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Antihypertensive sodium-proton exchanger (AHSP) proteins have garnered significant interest in the field of cardiovascular research due to their crucial role in regulating blood pressure and electrolyte balance. Originally identified as key players in cardiac and vascular function, AHSPs modulate sodium and hydrogen ion transport across cell membranes, impacting cellular homeostasis and overall cardiovascular health. Dysregulation of AHSP expression and function has been linked to various hypertensive disorders and heart diseases, highlighting their potential as therapeutic targets. Recent advances in protein engineering and recombinant DNA technology have enabled the production of recombinant AHSP proteins, facilitating in-depth studies of their structure-function relationships and physiological roles. Researchers are increasingly utilizing these recombinant proteins to investigate their mechanisms of action within cellular systems and animal models, aiming to elucidate how AHSPs contribute to hypertension and its associated pathologies. This growing body of research underscores the importance of AHSP proteins in cardiovascular health and paves the way for the development of novel interventions aimed at managing hypertension and improving patient outcomes.
