Analytical Data
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基因名
VIPR2
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简介
VIPR2 protein, serving as a receptor for Vasoactive Intestinal Peptide (VIP) and Pituitary Adenylate Cyclase-Activating Peptide (PACAP-38 and -27), activates adenylyl cyclase and can also couple with phospholipase C. Its versatile signaling pathways emphasize its pivotal role in transducing signals from VIP and PACAP, participating in cellular processes regulated by cyclic AMP and phosphoinositide signaling cascades. VIPR2 Protein, Human (HEK293, Fc) is the recombinant human-derived VIPR2 protein, expressed by HEK293 , with C-mFc labeled tag.
- Application
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别名
Vasoactive intestinal polypeptide receptor 2; VIP-R-2; PACAP-R3; VPAC2; VIPR2
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种属
Human
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表达系统
HEK293
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标签
C-mFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P41587
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表达区间
E24-V126
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蛋白长度
Partial
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分子量
45-60 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
VIPR2 (Vasoactive Intestinal Peptide Receptor 2) is a member of the G-protein coupled receptor family and plays a crucial role in various physiological processes, including neurotransmission and immune response regulation. Research has shown that VIP and its receptors, including VIPR2, are involved in neuroprotection, modulation of circadian rhythms, and various neurodegenerative diseases. Understanding the structure and function of VIPR2 is vital for the development of therapeutic strategies targeting disorders related to its dysregulation, such as anxiety, depression, and gastrointestinal diseases. The production of recombinant VIPR2 protein allows for in-depth studies of its signaling pathways, ligand interactions, and potential pharmacological inhibitors. By generating a recombinant form of VIPR2, researchers can dissect the receptor's role in cellular processes and contribute to the design of drugs that could modulate its activity, thereby offering new avenues for treatment options in related pathologies. The continuous exploration of VIPR2's molecular mechanisms also sheds light on the broader implications of vasoactive intestinal peptide signaling in health and disease.
