Analytical Data
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Gene name
TSPAN8
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简介
TSPAN8 is a cell surface glycoprotein that is complexed with integrins and belongs to the four-span protein family. It has four hydrophobic domains. TSPAN8 mediates extracellular signal transduction processes and regulates cell development, activation, growth, and movement. In addition, TSPAN8 is expressed in different cancers and has potential roles in cancer prognosis and targeted therapy. TSPAN8 Protein, Human (HEK293, His) is the recombinant human-derived TSPAN8 protein, expressed by HEK293 , with N-6*His labeled tag.
- Application
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Alternative Names
Tetraspanin-8; Tspan-8; CO-029; TSPAN8; TM4SF3
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Species
Human
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Source
HEK293
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Tag
N-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
P19075
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Expression Region
K110-N205
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Protein Length
Partial
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Molecular Weight
17&13 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TSPAN8, a member of the tetraspanin family, plays a crucial role in various biological processes, including cell adhesion, proliferation, and signaling pathways. Its expression has been implicated in cancer progression and metastasis, making it a potential biomarker and therapeutic target. Recent studies have shown that TSPAN8 can influence the tumor microenvironment by modulating interactions between cancer cells and surrounding stromal cells. The protein's ability to interact with other membrane proteins facilitates the formation of specialized microdomains, which can enhance signal transduction and contribute to cellular responses in malignancies. Additionally, TSPAN8 has been identified as a significant player in the metastasis of certain cancers, such as pancreatic and colorectal cancers, where it promotes the epithelial-mesenchymal transition (EMT). This has spurred research into TSPAN8 recombinant protein for therapeutic applications, with the aim of developing strategies that leverage its biological functions to inhibit tumor growth and metastasis. Understanding the structure-function relationship of TSPAN8 through recombinant protein studies could provide insights into its mechanisms and open avenues for innovative cancer treatments, highlighting its promise as a target for drug development. The ongoing exploration of TSPAN8 also includes its potential role in immune responses and its interactions with various signaling pathways, further underscoring its importance in both cancer biology and therapeutic strategies.
