Analytical Data
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Gene name
SLITRK1
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简介
The SLITRK1 protein is critical in synaptogenesis, promoting excitatory synaptic differentiation and synaptic maturation. Its effects extend to enhancing the growth of neuronal dendrites, emphasizing its importance in neuronal development. SLITRK1 Protein, Human (HEK293, His) is the recombinant human-derived SLITRK1 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
SLIT and NTRK-like protein 1; Leucine-rich repeat-containing protein 12; SLITRK1; KIAA1910; LRRC12
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Species
Human
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96PX8
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Expression Region
N18-S616
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Protein Length
Partial
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Molecular Weight
105-115 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLITRK1 (SLIT and NTRK-like protein 1) is a transmembrane protein that plays a crucial role in the development and function of the nervous system. It is primarily expressed in the brain and is involved in the regulation of neuronal connectivity, axon growth, and synaptic plasticity. Mutations and dysregulation of SLITRK1 have been associated with neurodevelopmental disorders, such as intellectual disabilities and autism spectrum disorders, indicating its significance in neurodevelopment. The interest in studying SLITRK1 recombinant proteins stems from the need to understand its molecular mechanisms and interactions. By producing SLITRK1 in a recombinant form, researchers aim to investigate its structural properties, binding affinity with other proteins, and potential signaling pathways. Furthermore, understanding SLITRK1's functional roles could provide insights into therapeutic strategies for neurological conditions linked to its dysfunction. The exploration of SLITRK1 recombinant proteins also opens avenues for elucidating the broader roles of similar SLITRK family members in neural and non-neural contexts. Overall, research on SLITRK1 recombinant proteins is pivotal for advancing our understanding of its contributions to brain function and its implications in neurodevelopmental disorders.
