Analytical Data
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Gene name
REG-3 alpha/REG3A
- Application
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Alternative Names
HIP; INGAP; PAP-H; PAP1; PBCGF; REG-III; REG3; Pancreatitis-Associated Protein; Hepatointestinal pancreatic protein; Human proislet peptide; Pancreatitis-associated protein 1
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
O09037
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Expression Region
Arg37~Gln175
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Molecular Weight
17kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
REG-3 alpha, also known as REG3A, is a key member of the regenerating gene family, primarily expressed in the pancreas and intestines. Its role in various physiological and pathological processes has garnered increasing attention in recent years. REG3A is recognized for its antimicrobial properties, particularly against Gram-positive bacteria, which positions it as a crucial component of the innate immune response in the gut. Additionally, it has been implicated in tissue regeneration and repair mechanisms, particularly following injury or inflammation, suggesting its potential as a therapeutic target in conditions such as pancreatitis, inflammatory bowel disease, and cancer. Recent studies have focused on the production and characterization of recombinant REG3A proteins to investigate their functional roles and therapeutic implications further. The development of REG3A as a recombinant protein allows for detailed biochemical studies and may facilitate the exploration of its potential applications in enhancing gut health and modulating immune responses. The ongoing research aims to unravel the molecular mechanisms underlying REG3A involvement in cellular processes, providing insights that could lead to novel therapeutic strategies for managing gastrointestinal disorders and other diseases linked to inflammation and tissue damage.
