Analytical Data
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Gene name
IL-1R9/IL1RAPL2
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简介
Interleukin-1 (IL-1) is a receptor that mediates gene expression for the synthesis of proteins associated with inflammation. IL1RAPL2 is associated with non-syndromic X-linked mental retardation. IL1RAPL2 is specifically expressed in the nervous system and is a candidate gene for central nervous system diseases. IL-1R9/IL1RAPL2 Protein, Human (HEK293, His) is the recombinant human-derived IL-1R9/IL1RAPL2 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Biological Activity
Immobilized Human IL-1R9 at 0.5 μg/mL (100 μL/well) can bind Human PTPRD. The ED50 for this effect is 136.4 ng/mL. Immobilized Human IL-1R9 at 0.5 μg/mL (100 μL/well) can bind Human PTPRD. The ED50 for this effect is 136.4 ng/mL.
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Alternative Names
X-linked interleukin-1 receptor accessory protein-like 2; IL1RAPL2; IL1R9
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q9NP60
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Expression Region
T17-E356
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Protein Length
Partial
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Molecular Weight
48-55 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IL-1R9, also known as IL-1 receptor accessory protein-like 2 (IL1RAPL2), is a member of the interleukin-1 receptor (IL-1R) family, which plays a crucial role in immune responses and inflammation. Recent studies have highlighted the importance of IL-1R9/IL1RAPL2 in various physiological and pathological processes, including neuroinflammation and synaptic functions in the central nervous system. This protein is primarily expressed in the brain and has been associated with neurodevelopmental disorders, suggesting its potential involvement in cognitive functions and neuropsychiatric conditions. Researchers have been focusing on the functional characteristics of IL-1R9/IL1RAPL2, including its interactions with IL-1 family cytokines and other signaling pathways, to elucidate its biological roles. Investigating recombinant IL-1R9/IL1RAPL2 proteins allows for a detailed understanding of its structure-function relationships and offers insights into therapeutic potential. By producing and characterizing this recombinant protein, scientists aim to develop novel strategies for targeting IL-1R9/IL1RAPL2 in various diseases, providing new avenues for treatment and understanding of immune and neurological disorders. Furthermore, understanding the signaling mechanisms mediated by IL-1R9/IL1RAPL2 could unveil new biomarkers for disease and highlight its potential as a therapeutic target in inflammatory and immunological diseases. Overall, the research surrounding IL-1R9/IL1RAPL2 is critical for advancing our knowledge of immune regulation and its implications for health and disease.
