Analytical Data
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基因名
NMNAT1
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简介
The NMNAT1 protein catalyzes the formation of NAD(+) from NMN and ATP and efficiently uses deamidated NaMN and triazofurane monophosphate as substrates. NMNAT1 Protein, Human (sf9, His) is the recombinant human-derived NMNAT1 protein, expressed by Sf9 insect cells , with C-His labeled tag.
- Application
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别名
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; NMNAT1; NMNAT
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种属
Human
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表达系统
Baculovirus
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9HAN9
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表达区间
M1-T279
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蛋白长度
Full Length
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分子量
34 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NMNAT1 (Nicotinamide Mononucleotide Adenylyltransferase 1) is an essential enzyme in the NAD+ biosynthesis pathway, playing a pivotal role in cellular energy metabolism and maintaining cellular homeostasis. Its significance extends beyond basic cellular functions; NMNAT1 is implicated in neuroprotection, as it is predominantly expressed in the brain. Research has demonstrated that NMNAT1 protects neurons from oxidative stress and apoptosis, indicating its potential as a therapeutic target in neurodegenerative diseases like Alzheimer’s and Parkinson’s. The reconstitution of NMNAT1 as a recombinant protein allows for detailed biochemical studies, providing insight into its catalytic mechanisms, substrate specificity, and regulation. Moreover, studying NMNAT1's structure and function can elucidate its role in NAD+ metabolism and its broader implications in aging and related disorders. By exploring NMNAT1 through recombinant protein technology, researchers aim to uncover novel therapeutic strategies to modulate its activity and enhance NAD+ levels in cells, potentially offering new avenues for treatment in conditions associated with energy metabolism dysregulation. This research emphasizes the importance of NMNAT1 not only in understanding fundamental biochemical pathways but also in developing interventions for age-related and neurodegenerative diseases.
