Analytical Data
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Gene name
CRABP2
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简介
CRABP2 (cellular retinoic acid binding protein 2) plays a crucial role in cellular processes by transporting retinoic acid into the nucleus and mediating its contact with nuclear retinoic acid receptors. CRABP2 interacts with RXR (retinoic acid X receptor) and RARA (retinoic acid receptor Alpha) to regulate the retinoic acid signaling pathway. CRABP2 Protein, Human (His) is the recombinant human-derived CRABP2 protein, expressed by E. coli , with N-His labeled tag.
- Application
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Alternative Names
Cellular retinoic acid-binding protein 2; CRABP-II; CRABP2
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Species
Human
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
P29373
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Expression Region
P2-E138
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Protein Length
Partial
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Molecular Weight
16 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CRABP2, or Cellular Retinoic Acid Binding Protein 2, is a member of the fatty acid-binding protein family and plays a crucial role in the transport and metabolism of retinoic acid, an active metabolite of vitamin A. Research on CRABP2 has gained significant attention due to its involvement in various biological processes, including cellular differentiation, growth, and apoptosis. Abnormal expression of CRABP2 has been linked to several pathological conditions, including cancer, where it affects tumor progression and response to therapy. Understanding the mechanistic role of CRABP2 in these processes necessitates the production of recombinant CRABP2 proteins, which can be utilized for functional assays, structural studies, and potential therapeutic applications. Recombinant protein expression allows for the study of CRABP2 in controlled environments, thereby facilitating detailed investigations into its binding properties, interaction with retinoic acid, and influence on gene expression regulation. Furthermore, the characterization of CRABP2 through recombinant methods provides insights into its potential as a biomarker for certain diseases and its viability as a target for novel therapeutic strategies. Overall, the exploration of CRABP2 through recombinant protein research is vital for elucidating its biological significance and therapeutic potential in various health conditions.
