Analytical Data
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Gene name
CRABP1
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简介
The CRABP1 protein is present in the cytoplasm and is involved in regulating the entry of retinoic acid into nuclear retinoic acid receptors. As an important molecular player, CRABP1 may mediate the complex process of interaction between retinoic acid and its nuclear receptor. CRABP1 Protein, Human is the recombinant human-derived CRABP1 protein, expressed by E. coli , with tag free.
- Application
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Alternative Names
Cellular retinoic acid-binding protein 1; CRABP-I; RBP5
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
AAH22069.1
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Expression Region
M1-E137
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Protein Length
Full Length
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Molecular Weight
14 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CRABP1 (Cellular Retinoic Acid-Binding Protein 1) plays a crucial role in the transport and signaling of retinoic acid, a metabolite of vitamin A that is essential for numerous biological processes, including cellular differentiation, gene expression modulation, and embryonic development. The study of CRABP1 has garnered significant interest due to its implications in various diseases, particularly cancer, where altered retinoic acid signaling has been linked to tumor progression and resistance to therapies. Research into CRABP1 recombinant protein helps delineate its binding properties and functional roles in cellular mechanisms. By producing CRABP1 as a recombinant protein in suitable expression systems, scientists can investigate its interactions with retinoic acid, identify specific binding domains, and assess its influence on gene regulation. This has potential implications for therapeutic strategies aimed at restoring normal retinoic acid signaling in cancer and other diseases. Moreover, understanding CRABP1's regulatory mechanisms can pave the way for novel drug development targeting retinoic acid pathways, significantly contributing to the broader field of molecular biology and medicine. Overall, the exploration of CRABP1 recombinant protein is vital for elucidating its molecular functions and therapeutic potential.
