Recombinant Rat Arginase-1/ARG1 Protein，His

Arginase-1 (ARG1), an enzyme that is crucial for the urea cycle, catalyzes the conversion of L-arginine to L-ornithine and urea. This enzyme plays a pivotal role not only in nitrogen metabolism but also in the regulation of various physiological and pathological processes, including immune response, tissue repair, and even cancer progression. Elevated ARG1 levels have been associated with the promotion of tumor growth and evasion of immune surveillance, as it can modulate immune cell function by depleting L-arginine, an essential amino acid for T cell activation. Consequently, researchers have focused on producing recombinant ARG1 proteins to better understand its enzymatic activity, regulation, and potential therapeutic applications. Recombinant protein studies have enabled the investigation of ARG1's structure-function relationships, as well as its interaction with inhibitors and substrates. Additionally, recombinant ARG1 can serve as a valuable tool for developing targeted therapies aimed at normalizing arginine metabolism in cancer and other diseases characterized by ARG1 overactivity. As a result, the exploration of ARG1 as both a biomarker and a therapeutic target has garnered significant interest in the fields of immunology and oncology, highlighting the need for more in-depth studies on its biological functions and clinical implications.