Analytical Data
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基因名
Der p 23
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简介
The Der p 23 protein was identified as a member of the allergic house dust mite proteins and does not exhibit chitin-binding ability in vitro. This unique feature distinguishes Der p 23 from other proteins known for their affinity to chitin, emphasizing its unique properties. Der p 23 Protein, Dermatophagoides pteronyssinus (HEK293, His) is the recombinant Der p 23 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
Major mite allergen Der p 23; Peritrophin-like protein Der p 23; Der p 23
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种属
Others
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
L7N6F8
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表达区间
A22-T90
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蛋白长度
Full Length of Mature Protein
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分子量
19 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Der p 23 is a major allergen derived from the house dust mite Dermatophagoides pteronyssinus, known for its significant role in triggering allergic reactions and asthma in sensitized individuals. As a highly prevalent source of indoor allergens, Der p 23 has garnered considerable attention in allergy research. The recombinant form of this allergen allows for a deeper understanding of its immunological properties, facilitating the development of targeted diagnostic tools and therapeutic interventions. Studies involving Der p 23 have demonstrated its ability to elicit strong IgE antibody responses, which are critical in the pathogenesis of allergic diseases. Additionally, research has focused on the protein's structural characteristics, revealing how specific epitopes interact with IgE and contribute to allergic sensitization. Understanding these mechanisms is vital for designing allergen-specific immunotherapies, potentially leading to better management strategies for allergic diseases. Moreover, advancements in recombinant technology have enabled the production of Der p 23 in a controlled environment, reducing the risk of contamination and variability associated with natural sources, and providing a valuable resource for clinical and experimental studies. Overall, the investigation of Der p 23 as a recombinant protein plays a pivotal role in elucidating the underlying mechanisms of allergenicity and in improving allergy diagnostics and treatments.
