Analytical Data
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Gene name
STK4
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简介
MST1/STK4 protein is a stress-activated kinase that is critical in the Hippo signaling pathway and can induce apoptosis and regulate hepatocyte proliferation. Cleaved MST1/STK4 enters the nucleus, causing chromatin condensation and DNA fragmentation. STK4 Protein, Human (His) is the recombinant human-derived STK4, expressed by E. coli, with His labeled tag.
- Application
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Species
Human
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Source
E. coli
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Tag
His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13043-1
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Expression Region
E2-E311
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
STK4, also known as Serine/Threonine Kinase 4, is a pivotal member of the dual-specificity kinase family, with significant roles in various cellular processes, including cell cycle regulation, apoptosis, and stress response. Research on STK4 has gained momentum due to its association with several physiological and pathological conditions, such as cancer and immune responses. It has been demonstrated that STK4 functions as a negative regulator of NF-κB signaling, which is crucial for inflammation and immune system modulation. Given STK4's integral role in these pathways, recombinant STK4 proteins have become a focal point for understanding its mechanism of action and potential therapeutic applications. By producing and characterizing recombinant STK4, researchers aim to explore its enzymatic activity, interaction with other cellular proteins, and its effect on downstream signaling pathways. Moreover, the study of STK4 in various contexts, including cancer biology and immunology, may unveil novel insights into its role as a therapeutic target or biomedically relevant protein. Thus, the exploration of STK4 recombinant proteins not only contributes to our fundamental understanding of cellular regulation but also informs strategies for disease intervention.
