Analytical Data
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Gene name
MAP4K1
- Application
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Alternative Names
MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1
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Species
Human
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Source
Baculovirus
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92918-1
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Expression Region
M1-G297
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MAP4K1, also known as mitogen-activated protein kinase kinase kinase 4, is a member of the MAP3K family and plays a crucial role in various cellular processes, including apoptosis, proliferation, and differentiation. Research on MAP4K1 has gained significance due to its involvement in key signaling pathways, particularly the c-Jun N-terminal kinase (JNK) and p38 MAPK pathways, which are critical for stress responses and inflammatory processes. Abnormal MAP4K1 activity has been linked to several diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. Its pivotal role in these pathways makes MAP4K1 a potential therapeutic target for drug development. Recent studies have focused on the recombination and analysis of MAP4K1 protein to understand its structure-function relationship and regulatory mechanisms. By generating recombinant MAP4K1 proteins, researchers aim to elucidate its interactions with other proteins and signaling molecules. Moreover, the study of MAP4K1's functional domains via recombinant technology allows for detailed investigations into its enzymatic activity and downstream effects on cellular signaling. Understanding MAP4K1 at a molecular level is crucial for developing targeted therapies that can modulate its function in disease contexts, highlighting its potential as a promising target in biomedical research.
