Analytical Data
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基因名
CDK5-p35
- Application
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别名
PSSALRE; CDKN5; Cell division protein kinase 5; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit;TPKII catalytic subunit
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q00535
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表达区间
Met1~Pro292
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分子量
37kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Cyclin-dependent kinase 5 (CDK5) is a serine/threonine kinase that plays a crucial role in the regulation of neuronal development and function. Unlike other cyclin-dependent kinases, CDK5 is activated by specific regulatory proteins, specifically p35 and p39. The CDK5-p35 complex is critical for various cellular processes, including neurogenesis, synaptic plasticity, and the maintenance of neuronal architecture. Abnormal activation of CDK5 has been implicated in various neurodegenerative diseases, such as Alzheimer's disease, where the cleavage of p35 into p25 leads to hyperactivation of CDK5, contributing to neurotoxicity and neurofibrillary tangle formation. Research on recombinant CDK5-p35 proteins has gained significant interest as a means to understand the kinase's specific roles in neuronal signaling and pathology. This protein has been studied for its structural properties, enzymatic activity, and interactions with other proteins involved in cellular signaling pathways. By generating and analyzing recombinant CDK5-p35, researchers aim to delineate the precise mechanisms by which CDK5 influences neuronal health and its potential as a therapeutic target for neurodegenerative disorders. Understanding the CDK5-p35 pathway is critical, as it may reveal valuable insights into preventing or treating conditions characterized by neuronal dysfunction.
