Analytical Data
-
Gene name
Neurotrophin-4
-
简介
Neurotrophin-4 (NT-4) protein serves as a vital target-derived survival factor for peripheral sensory sympathetic neurons, emphasizing its crucial role in promoting their survival and maintenance. The specific and targeted actions of NT-4 underscore its significance as a neurotrophic factor in the intricate mechanisms governing the well-being of peripheral neurons within the sympathetic nervous system. Neurotrophin-4 Protein, Human (His) is the recombinant human-derived Neurotrophin-4 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
-
Alternative Names
rHuNT-4; NT-5; NTF4; NTF5; NT4
-
Species
Human
-
Source
E. coli
-
Tag
N-6*His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P34130
-
Expression Region
V82-A210
-
Protein Length
Partial
-
Molecular Weight
18 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Related Products
Protein Description
Neurotrophin-4 (NT-4) is a pivotal member of the neurotrophin family, which plays a crucial role in the survival, development, and function of neurons. It specifically aids in the differentiation and maintenance of certain neuronal populations, particularly those in the peripheral and central nervous systems. The significance of NT-4 arises from its ability to bind to the neurotrophin receptors TrkB and p75NTR, which are essential for neuronal signaling. Research has shown that NT-4 can promote neuronal survival and reduce cell death, making it a potential therapeutic candidate for neurodegenerative diseases and nerve injuries. Moreover, NT-4 has been of particular interest in the context of clinical applications, including the treatment of neuropathies and cognitive impairments. The recombinant production of NT-4 has enabled scientists to explore its biological functions and therapeutic potential more extensively. Advancements in recombinant DNA technology have facilitated the large-scale production of NT-4, allowing for in-depth studies into its structure-function relationships and interactions with other cellular components. As research continues, understanding the precise mechanisms by which NT-4 influences neuronal health and plasticity could lead to novel interventions for a range of neurological disorders. Overall, the exploration of NT-4 recombinant proteins represents a promising avenue for both basic neuroscience research and the development of innovative therapeutic strategies.
